I am getting more comfortable with PSE-10. At first I hated it because it tried to do things for me that I didn't want to do (LIKE OPEN EVERY IMAGE FROM EVERY PROGRAM that I open in my computer). I would also far prefer to dump the PSE way of storing a library of photos. I enjoyed working in CS-5 which did not have that capability (or that anchor as far as my workflow goes).
When using CS-5 to asemble a panorama, Content Aware Fill will enable me to fill in the areas (usually sky and foreground) that are not covered by the assembled panorama. This is a great and simple tool which works very well.
PSE-10 doesn't have a global Content Aware Fill (although I think that PSE-9 did have one). PSE-10 uses a Content Aware Fill Brush which, IMO, is no where nearly as efficient as the global Content Aware Fill.