Hi Cheryl,
It's the stuff "books are written about" (so hard to articulate in just a few sentences), but for an image like yours, standard settings would work pretty well ... so ... assuming a RAW capture then:
Capture sharpening of 0.3 @ 300%
Content / creative sharpening of 4px @ 40%
(both of the above on the full resolution image)
and then (after down-sampling) ...
Output sharpening in the region of 0.3px @ 50 t0 100%
I've written a bit about it in the past - you might find this helpful ...
Sharpening and Noise Reduction Sequence
Having just said all that, portraiture requires a lot of additional post-processing around the eye area - including additional localised sharpening.
Does that help?