I read these comments in a Canon Professional Network article "tips" section and would welcome comments and responses:
"Any lens will be at its sharpest between two and four stops down from maximum aperture; f/5.6 to f/8 for an f/2,8 lens. Need more depth of field? Don't stop the lens down beyond f/11, check out hyperfocal distance on Google or get a Tilt and Shift (TSE) lens."
altosax