I've been using refillable cartridges with Lyson Inks in my Epson R2400 for a couple of years now with very few problems. I find that the colour rendering is very good once you have a custom profile - it's noticeably off if you use the default Epson or Lyson Profile. The only problems I've had is that the heads seem to clog up more often than I used to have with the OEM inks.
I'm not a regular printer, but do many prints in batches from time to time. Not having done anything for 3-4 mths I thought that I would get some new refillable cartridges as the old ones were looking decidedly mucky and I'm not sure the ink flow was good on one or two.
I went to my usual source and got a new set but noticed on arrival that 7 cartridges appeared physically similar to my old set but one was different - Yellow for what its worth. The printer immediately flagged the Yellow cartridge as empty and nothing I could do would convince it otherwise. The supplier sent a replacement which did just the same.
They then sent a complete new set of all the same type but of the new design. In this set 3 other cartridges were immediately flagged as empty. But even worse was that when I took out the first new set to put these in, three cartridges had lost all the ink even though they had not been used and no cleaning cycles had been run.
In the end I got a complete refund and bought a set of OEM inks to keep me going.
So, a word of caution..... Some refillable ink cartridges just don't work and others leak ink rapidly.
The supplier was very helpful but in the end couldn't fix the problem.