My daughter and I tried something along these lines a number of years ago and we spent a couple of hours in the studio shooting. The colours come through the use of gelled studio lights, rather than being "artificially" created in post-processing.
Around 20 layers so far and I expect I will do some more tuning or use some of the other shots I took to create a triptych of sorts. I don't think I'm done yet, but need to think about where I will take this shot.