When I upgraded my Canon 5D Mark III not long ago, the primary reason I chose the 5D Mark IV over the R5 was price. Net of selling my old camera, the R5 would have cost me 2.5 times as much, because it's a new model and the Mark IV was on sale for a month. Nonetheless, I had a list of pros and cons. One of the (hypothetical, as it turns out) cons for the R5 was the possibility of greater noise from smaller photosites (45 vs. 30 mpx). Turns out not to be the case: improvements in sensor and amplification technology apparently offset the difference.
I don't understand the reason for the big non montonicity between ISO 320 and 400 on the R5, but the notes at the bottom have a few clues.
It's hard to read at this size, so I'll note that blue is the R5.